API TR 412 and 414

This two-part inhalation study sought to specifically evaluate the potential of unleaded gasoline for developmental toxicity in rodents. The composition of the unleaded gasoline vapor condensate and the treatment pattern used are representative of real-world exposure conditions encountered at service stations and in other occupational settings. The results show that developmentally there were no differences between treated and control groups in malformations, total variations, resorptions, fetal body weight, or viability. Under the conditions of the study, unleaded gasoline vapors did not produce evidence of developmental toxicity. (This volume includes publications TR 412 and TR 414.)